Which strategy in inhibition of the renin-angiotensin system is the most efficient for heart failure?
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چکیده
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Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure.
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متن کاملThe renin-angiotensin system and experimental heart failure.
Experimental studies suggest that the renin-angiotensin system (RAS) and its primary effector peptide, angiotensin II (Ang II), are involved in the pathophysiology of cardiac hypertrophy and failure. All the components required for Ang II production are present in the heart, and cardiac Ang II formation appears to be regulated independent from the circulating RAS. In animal models and in patien...
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Heart failure (HF) remains the most common cause of death and disability, and a major economic burden, in industrialized nations. Physiological, pharmacological, and clinical studies have demonstrated that activation of the renin-angiotensin system is a key mediator of HF progression. Angiotensin-converting enzyme 2 (ACE2), a homolog of ACE, is a monocarboxypeptidase that converts angiotensin I...
متن کاملInhibition of the renin–angiotensin system
• In patients with established evidence-based indications for inhibition of the renin–angiotensin system, for example congestive cardiac failure or chronic kidney disease with proteinuria, this treatment should not generally be withheld on the basis of renovascular disease. • When an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) are used in patients with re...
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ژورنال
عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System
سال: 2008
ISSN: 1470-3203,1752-8976
DOI: 10.1177/1470320308097418